Calcium channel blocker and renal mitochondrial function in warm renal ischemia
نویسندگان
چکیده
منابع مشابه
Calcium channel blocker and renal mitochondrial function in warm renal ischemia.
OBJECTIVE Ions, particularly calcium ions, play an important role in ischemia-reperfusion cell injury. In this study, we investigated the action of verapamil on the mitochondrial function of kidneys submitted to ischemia without blood reperfusion in order to study isolated early and late ischemic effects. MATERIALS AND METHODS 44 rats were submitted to bilateral warm renal ischemia for 30 min...
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BACKGROUND AND PURPOSE Recent preclinical data have indicated that erythropoietin (Epo) can protect organs from ischemic damage. We evaluated the ability of Epo to protect the kidney from the effects of ischemia. METHODS Thirty dogs underwent a laparoscopic nephrectomy and were allowed to recover for 2 weeks. The dogs were then divided into five groups. Animals in groups 1 and 2 underwent 1.5...
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Introduction: This study investigated the effect of berberine on renal dysfunction and histological damages of the lung induced by renal ischemia/ reperfusion at an early stage. Methods: There were four experimental groups of adult male rats (n=7). Seven days before induction of ischemia, the Ber+I/R group received oral (by gavage) berberine (15 mg/kg/day) while the I/R group received distil...
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Purpose: To evaluate the influence of ischemia/reperfusion injury on renal compensatory growth (CGR) and mitochondrial function. Methods: Forty five Wistar rats were divided in 3 groups: Control Group (GC) – 21 rats were submitted to a sham laparotomy and sacrificed at 1 (6 rats) and 7 (15 rats) postoperative days to evaluate the dry weight of both kidneys and their growth during 1 week (6 rats...
متن کاملRenal Microcirculation and Calcium Channel Subtypes
It has recently been reported that voltage-dependent Ca channel subtypes, e.g., L-, T-, N-, and P/Q-type, are expressed in renal arterioles and renal tubules, and the inhibition of these channels exerts various effects on renal microcirculation. For example, selective blockade of L-type Ca channels with nifedipine preferentially dilates the afferent arteriole and potentially induces glomerular ...
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ژورنال
عنوان ژورنال: International braz j urol
سال: 2005
ISSN: 1677-5538
DOI: 10.1590/s1677-55382005000400014